Sisters Kat and Daisy work along with Jojo at the pizza parlour in Mystic, Connecticut. Kat, shortly off to Yale, finds herself drawn to a local architect she is babysitting for, while her more tearaway sister starts dating a guy from the money side of the tracks. Jojo leaves her man at the altar; she loves him but shies away from commitment. Meanwhile the fame of the pizza continues to spread; it seems to contain something almost ..... mystic.

Helen, a writer, and Madeline, an actress, have hated each other for years. Madeline is married to Ernest, who was once Helen's fiance. After she recovers from a mental breakdown, Helen vows revenge by stealing back Ernest and plotting to kill Madeline. Both rivals have secretly drunk a miracle cure for aging; they accidentally discover, when each tries to eliminate the other, that they have become immortal and that "life" will never be the same again.